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The U.S. Joint Program Office for Biological Defense (JPOBD) is a division of the U.S. Department of Defense (DOD) that is responsible for coordinating and managing the development and procurement of medical countermeasures and other technologies to protect military personnel and the general public from biological threats.

The JPOBD was established in 2003 to address the emerging threat of bioterrorism and to enhance the military's ability to respond to biological attacks. It works closely with other federal agencies, such as the U.S. Department of Health and Human Services (HHS), to ensure that the military has access to the latest technologies and medical countermeasures to protect against biological threats.

The JPOBD is responsible for managing a number of programs and initiatives, including the development of vaccines, therapies, and diagnostic tests to protect against biological agents, as well as the procurement of medical countermeasures and other technologies to support the military's preparedness efforts. The JPOBD also plays a key role in coordinating the response to biological incidents, including providing technical assistance and advising on the deployment of medical countermeasures.