The President's Emergency Plan for AIDS Relief (PEPFAR) is a program of the United States government that is focused on combating the HIV/AIDS pandemic. It was established in 2003 by President George W. Bush and has since become the largest commitment by any nation to address a single disease in history. PEPFAR works to prevent the spread of HIV, to provide care and treatment for people living with HIV, and to support those affected by the disease. The program operates in more than 50 countries around the world and is funded through a combination of federal appropriations and private donations. PEPFAR has made a significant impact in the global fight against HIV/AIDS and is widely recognized as a model for international development efforts.